Peanut allergy – Allergy testing: Skin prick test, Specific IgE (RAST), ISAC
Oral Immunotherapy to peanuts was tried but is still very dangerous for clinical practice.
Molecular allergy in peanut allergy can help to predict severity of food allergy.
What is the difference?
As any in any allergy people allergic to peanuts are allergic to a protein. There are many different proteins in peanuts some of them are more stable and cause serious anaphylactic reactions but some of them are less stable and are easily destroyed by temperature and digestion in the result cause less severe symptoms.
It is very important to know which protein – component of peanut allergen the patient is allergic to.
Knowing this can predict the severity of the next reaction on accidental exposure to peanut.
Many allergen components for peanuts are included into biochip blood test called ISAC (among 104 allergen components on the chip tested all at once in one go).
This test is available in our centre for children and adults Our consultants will interpret the results for you.
List of allergenic moleculs in peanuts:
| Ara h 1 | Storage Protein (Vicilin) | |
| Ara h 2 | Storage Protein (Conglutin) | |
| Ara h 3 | Storage Protein (Glycin) homology with Ara h 4 | |
| Ara h 4 | Storage Protein (Glycin) homology with Ara h 3 | |
| Ara h 5 | Profilin, highly cross-reacting, low risk | |
| Ara h 6 | Storage Protein (Conglutin) Similar to Ara h 2 | |
| Ara h 7 | Conglutin. Homology with Ara h 2 | |
| Ara h 8 | PR-10, Bet v 1-homolog, cross-reactive w. birch | |
| Ara h 9 | Lipid Transfer Protein (LTP), high risk, regional difference | |
| Ara h 10 | 16 kD Oleosin | |
| Ara h 11 | 14 kD Oleosin |