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ISAC Test: 112 Allergy Tests in one tiny blood sample!

A private Allergy ISAC test can test for 112 allergies in one tiny blood sample! The ISAC test is a blood test that uses microchip technology to detect specific IgE antibodies to food and airborne allergens (this test uses method called ELISA with a special reader; it replaced the test previously called RAST). It allows  simultaneous measurement of specific antibodies to multiple allergen components in a single test, using only a few µl of serum or plasma. The allergens are pre-selected and include the most relevant specie specific and cross-reactive markers.

A combination of innovative biochip technology with cutting edge research in molecular allergology has resulted in ImmunoCAP® ISAC – the most advanced in vitro diagnostic test for simultaneous measurement of specific IgE antibodies to a broad spectrum of allergen components.

 

This test is now available all over the UK in England, Scotland, Wales and Northern Ireland as well as for some international customers with the new self finger prick collection and sample in the post technology.

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Allergy testing is easy now there is even no need to travel to the clinic to have this test done!

You will receive report with interpretation of results from one of our Allergy and Immunology consultants!
Please e-mail us for details
In London you can attend our adult or paediatric allergy clinic or laboratory where blood sample can be taken

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The specific IgE chip delivers results for over a hundred components from more than 50 allergen sources

(see the list of allergens below).

The ImmunoCAP® ISAC test provides a large amount of allergen specific IgE  antibody information – the big picture – in a single step. This enables
patient investigations that require less time and resources. As a result, effective and optimized management can be started earlier, which in turn leads to improved patient health and quality of life. This test is relatively inexpensive comparing with the price of testing of sIgE to allergens individually.

 List of allergens tested in one test in a single blood sample from a finger prick

Allergen Component Allergen Source Latin Name Protein Group On Immunocap?
FOOD ALLERGENS


     
nGal d 1 Egg Gallus domesticus Ovomucoid Y
nGal d 2 Egg Gallus domesticus Ovalbumin Y
nGal d 3 Egg Gallus domesticus Conalbumin/Ovotransferrin Y
nGal d 5 CSA (Livetin) Gallus domesticus Serum albumin N
nBos d 4 Cow’s milk Bos domesticus Alpha-lactalbumin Y
nBos d 5 Cow’s milk Bos domesticus Beta-lactoglobulin Y
nBos d 6 BSA Bos domesticus Serum albumin Y
nBos d 8 Cow’s milk Bos domesticus Casein Y
nBos d lactoferrin Cow’s milk Bos domesticus Transferrin Y
rGad c 1 Cod Gadus callarias Parvalbumin Y
nPen m 1 Shrimp Penaeus monodon Tropomyosin N
nPen m 2 Shrimp Penaeus monodon Arginine kinase N
nPen m 4 Shrimp Penaeus monodon Sarcoplasmic Ca-binding protein N
rAna o 2 Cashew nut Anacardium occidentale Storage protein, 11S globulin N
rBer e 1 Brazil nut Bertholletia excelsa Storage protein, 2S albumin Y
rCor a 1.0401 Hazelnut Corylus avellana PR-10 protein Y
rCor a 8 Hazelnut Corylus avellana Lipid transfer protein (nsLTP) Y
nCor a 9 Hazelnut Corylus avellana Storage protein, 11S globulin N
nJug r 1 Walnut Juglans regia Storage protein, 2S albumin N
nJug r 2 Walnut Juglans regia Storage protein, 7S globulin N
nJug r 3 Walnut Juglans regia Lipid transfer protein (nsLTP) N
nSes i 1 Sesame seed Sesamum indicum Storage protein, 2S albumin N
rAra h 1 Peanut Arachis hypogaea Storage protein ,7S globulin Y
rAra h 2 Peanut Arachis hypogaea Storage protein, Conglutin Y
rAra h 3 Peanut Arachis hypogaea Storage protein, 11S globulin Y
nAra h 6 Peanut Arachis hypogaea Storage protein, Conglutin N
rAra h 8 Peanut Arachis hypogaea PR-10 protein Y
rAra h 9 Peanut Arachis hypogaea Lipid transfer protein (nsLTP) Y
rGly m 4 Soybean Glycine max PR-10 protein Y
nGly m 5 Soybean Glycine max Storage protein, Beta-conglycinin Y
nGly m 6 Soybean Glycine max Storage protein, Glycinin Y
nFag e 2 Buckwheat Fagopyrum esculentum Storage protein, 2S albumin N
rTri a 14 Wheat Triticum aestivum Lipid transfer protein (nsLTP) N
rTri a 19.0101 Wheat Triticum aestivum Crude gliadin Y
nTri a aA_TI Wheat Triticum aestivum Omega-5 gliadin N
nAct d 1 Kiwi Actinidia deliciosa   N
nAct d 2 Kiwi Actinidia deliciosa Thaumatine-like protein N
nAct d 5 Kiwi Actinidia deliciosa   N
rAct d 8 Kiwi Actinidia deliciosa PR-10 protein Y
rApi g 1 Celery Apium graveolens PR-10 protein Y
rMal d 1 Apple Malus domestica PR-10 protein N
rPru p 1 Peach Prunus persica PR-10 protein Y
rPru p 3 Peach Prunus persica Lipid transfer protein (nsLTP) Y
         
AEROALLERGENS


     
nCyn d 1 Bermuda grass Cynodon dactylon Grass group 1 Y
rPhl p 1 Timothy grass Phleum pratense Grass group 1 Y
rPhl p 2 Timothy grass Phleum pratense Grass group 2 Y
nPhl p 4 Timothy grass Phleum pratense   Y
rPhl p 5 Timothy grass Phleum pratense Grass group 5 Y
rPhl p 6 Timothy grass Phleum pratense   Y
rPhl p 7 Timothy grass Phleum pratense Polcalcin Y
rPhl p 11 Timothy grass Phleum pratense   Y
rPhl p 12 Timothy grass Phleum pratense Profilin Y
rAln g 1 Alder Alnus glutinosa PR-10 protein N
rBet v 1 Birch Betula verrucosa PR-10 protein Y
rBet v 2 Birch Betula verrucosa Profilin Y
rBet v 4 Birch Betula verrucosa Polcalcin, Calcium bonding protein Y
rCor a 1.0101 Hazel pollen Corylus avellana PR-10 protein N
nCry j 1 Japanese ceder Cryptomeria japonica   N
nCup a 1 Cypress Cupressus arizonica   Y
nOle e 1 Olive Olea europaea   Y
nOle e 7 Olive Olea europaea Lipid transfer protein (nsLTP) N
rOle e 9 Olive Olea europaea   N
rPla a 1 Plane tree Platanus acerifolia   N
nPla a 2 Plane tree Platanus acerifolia   N
rPla a 3 Plane tree Platanus acerifolia Lipid transfer protein (nsLTP) N
nAmb a 1 Ragweed Ambrosia artemisiifolia   Y
nArt v 1 Mugwort Artemisia vulgaris   Y
nArt v 3 Mugwort Artemisia vulgaris Lipid transfer protein (nsLTP) Y
rChe a 1 Goosefoot Chenopodium album   N
rMer a 1 Annual mercury Mercurialis annua Profilin N
rPar j 2 Wall pellitory Parietaria judaica Lipid transfer protein (nsLTP) Y
rPla l 1 Plantain (English) Plantago lanceolata   N
nSal k 1 Saltwort Salsola kali   Y
rCan f 1 Dog Canis familiaris Lipocalin Y
rCan f 2 Dog Canis familiaris Lipocalin Y
nCan f 3 Dog Canis familiaris Serum albumin Y
rCan f 5 Dog Canis familiaris Arginine esterase N
rEqu c 1 Horse Equus caballus Lipocalin N
nEqu c 3 Horse Equus caballus Serum albumin N
rFel d 1 Cat Felis domesticus Uteroglobin Y
nFel d 2 Cat Felis domesticus Serum albumin Y
rFel d 4 Cat Felis domesticus Lipocalin N
nMus m 1 Mouse Mus musculus Lipocalin N
rAlt a 1 Alternaria Alternaria alternata   Y
rAlt a 6 Alternaria Alternaria alternata Enolase N
rAsp f 1 Aspergillus Aspergillus fumigatus   Y
rAsp f 3 Aspergillus Aspergillus fumigatus   Y
rAsp f 6 Aspergillus Aspergillus fumigatus Mn superoxide dismutase Y
rCla h 8 Cladosporium Cladosporium herbarum   N
rBlo t 5 House dust mite Blomia tropicalis   N
nDer f 1 House dust mite Dermatophagoides farinae   N
rDer f 2 House dust mite Dermatophagoides farinae   Y
nDer p 1 House dust mite Dermatophagoides pteronyssinus   Y
rDer p 2 House dust mite Dermatophagoides pteronyssinus   Y
rDer p 10 House dust mite Dermatophagoides pteronyssinus Tropomyosin Y
rLep d 2 Storage mite Lepidoglyphus destructor   N
rBla g 1 Cockroach Blattella germanica   N
rBla g 2 Cockroach Blattella germanica   N
rBla g 5 Cockroach Blattella germanica   N
nBla g 7 Cockroach Blattella germanica Tropomyosin N
         
OTHER


     
rApi m 1 Honey bee venom Apis mellifera Phospholipase A2 Y
nApi m 4 Honey bee venom Apis mellifera Melittin N
rPol d 5 Paper wasp venom Polistes dominulus Venom, Antigen 5 Y
rVes v 5 Common wasp venom Vespula vulgaris Venom, Antigen 5 Y
rAni s 1 Anisakis Anisakis simplex   N
rAni s 3 Anisakis Anisakis simplex Tropomyosin N
rHev b 1 Latex Hevea brasiliensis   Y
rHev b 3 Latex Hevea brasiliensis   Y
rHev b 5 Latex Hevea brasiliensis   Y
rHev b 6.01 Latex Hevea brasiliensis   Y
rHev b 8 Latex   Profilin Y
nMUXF3 Sugar epitope from Bromelain   CCD-marker Y

Storage protein

• Proteins stable to heat and digestion causing reactions also to  cooked foods.
• often associated with systemic and more severe reactions in addition to OAS.
• Proteins found in nuts and seeds serving as source material during  the growth of a new plant.

LTP (non-speciἀc Lipid Transfer Protein, nsLTP)

• Proteins stable to heat and digestion causing reactions also to  cooked foods.
• often associated with systemic and more severe reactions in addition  to OAS.
• Associated with allergic reactions to fruit and vegetables especially  in regions where peach and closely related fruits are cultivated.

Pr-10 protein, Bet v 1 homologue

• most PR-10 proteins are sensitive to heat and digestion and cooked foods are often tolerated.
• often associated with local symptoms such as oral allergy syndrome (OAS).
• Associated with allergic reactions to pollens, fruits and vegetables.

Proflin

• Proteins sensitive to heat and digestion and cooked foods are often tolerated.
•  Seldom associated with clinical symptoms but may cause local and even severe reactions in some patients.
• Profilins ae present in all pollen and plant foods.

CCD

• A marker for sensitization to cross-reactive carbohydrate determinants.
• Rarely causes allergic reactions, but may produce positive in-vitro test results to CCd-containing allergens from pollen, plant foods, insects  and venoms.

Tropomyosin

• Proteins stable to heat and digestion causing reactions also to cooked foods. • As food allergen often associated with systemic and more severe reactions in addition to OAS.
• Actin-binding proteins in muscle fibres and a marker for cross-reactivity between crustaceans, mites and cockroach.

Parvalbumin

• Proteins stable to heat and digestion causing reactions also to cooked foods.
• often associated with systemic and more severe reactions in addition to OAS.
• major allergens in fish and a marker for cross-reactivity among different species of fish and amphibian.

Serum albumin

• Proteins fairly sensitive to heat and digestion.
• Proteins present in different biological fluids and solids in all animals e.g.: cow’s milk, blood, beef and epithelia.
• Cross-reactions between albumins from different mammalian species are well known, for example between cat and dog and cat and pig (pork).

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