Interleukin-25 induces type 2 cytokine production in a steroid-resistant interleukin-17RB+ myeloid population that exacerbates asthmatic pathology
Posted: 23rd July 2013 | Posted by AdminMR
Researchers from the University of Michigan Health System have discovered a new type of cell in mice that appears to be crucial to causing asthma symptoms—even in the presence of steroid. Their findings, published in the journal Nature Medicine, also showed that people with asthma have a very similar cell type in their blood at higher levels than people without the condition.
The research may help explain what’s going on in the lungs of steroid-resistant individuals with asthma. In addition, the findings could aid in the development of new treatment options, and of better ways to identify people at risk of becoming steroid-resistant.
The new cell type, dubbed T2M, for type 2 myeloid, was shown to receive specific distress signals sent out by cells in the lung lining, and to produce molecules that lead to more inflammation. The researchers discovered the cells while examining the role of a signaling molecule called interleukin 25 (IL-25).