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Immunotherapy allergy treatment

International consensus on allergen immunotherapy-II: Mechanisms, standardization, and pharmacoeconomics
This month, JACI presents the second portion of the comprehensive international consensus (ICON) statement on allergen immunotherapy. The ICON statement is an effort of the International Collaboration in Asthma, Allergy and Immunology (iCALL) that includes the European Academy of Allergy and Clinical Immunology (EAACI), the American Academy of Allergy, Asthma and Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the World Allergy Organization (WAO). Jutel et al. review the evidence on how allergen immunotherapy (AIT) works and summarize what lies on the horizon (J Allergy Clin Immunol 2016; 137(2): 358-368).

A number of mechanisms underlie an allergic response to a substance such as grass pollen, house dust mites, or bee venom. Allergen immunotherapy involves slowly increasing exposure to an allergen over time, ideally resulting in a patient’s increased tolerance and clinical improvement. The literature indicates that administration of AIT leads to early decreases in the susceptibility of mast cells and basophils to respond to environmental proteins, even in the presence of elevated allergen-specific immunoglobulin (Ig)E. Desensitization is followed by allergen-specific T-regulatory (Treg) and B-regulatory (Breg) cell generation and regulation of allergen-specific IgE and IgG4. In the longer term, changes in memory T- and B-cell compartments and shift in the balance of type 1 T-helper (Th1) and type 2 T-helper (Th2) cells result in sustained improvement.

Effects of Anaphylaxis on the Body

Effects of Anaphylaxis on the Body

Immune System


The Effects of Anaphylaxis on the Body

Written by Ann Pietrangelo | Published on August 25, 2014
Medically Reviewed by George Krucik, MD, MBA on August 25, 2014

You may have a food intolerance or a minor allergic reaction to something you come into contact with, but that pales in comparison to anaphylaxis. Almost any substance can be an allergen, including foods and insect bites or stings. The cause can’t always be pinpointed. The first time you’re exposed to the substance, your immune system learns to recognize the foreign invader. In anaphylaxis, when you’re exposed again, your immune system has an exaggerated response that affects the whole body and may put your life in danger. Symptoms may begin within seconds and they can progress swiftly.

The first line of treatment is usually adrenaline, because it can turn things around quickly. Once you’ve experienced anaphylaxis, you’re always at risk, so you should take great caution to avoid the triggering substance.

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Wheat allergy oral immunotherapy for children

Wheat allergy oral immunotherapy for children

“most of the children that received this new oral immunotherapy treatment were able to eat 100 grams of wheat bread without side effects. This result has overcome the risk of accidental ingestion by patients with this allergy. This research could be the basis for large clinical trials with more patients with the aim of assessing the therapeutic benefit of this new approach.

Wheat is one of the most frequent childhood food allergies (about the 35% at the age of 12). ”

Study assesses therapeutic benefits of new oral immunotherapy for children allergic to wheat

Cat Dog pet allergy Treatment

Cat Dog pet allergy Treatment

Consultants in the London Allergy and Immunology Centre can help to diagnose allergy to animals and in many cases advice can be given how to avoid symptoms with  treatment can significantly improve allergy to pets.

Cat Dog pet allergy Treatment

Atopic Dermatitis Food Allergy

Atopic Dermatitis Food Allergy

Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods

  1. C.D. van Ginkel1,2,*,
  2. B.M.J. Flokstra–de Blok2,3,
  3. B.J. Kollen3,
  4. J. Kukler1,
  5. G.H. Koppelman1,2,† and
  6. A.E.J. Dubois1,2,†

DOI: 10.1111/all.12569

Atopic dermatitis Food allergy

Atopic dermatitis Food allergy




New technique reveals immune cell motion through variety of tissues

Christmas in London

We are open again on the 2 January 2015

Happy Holidays


Vitamin D Supplements Improve Urticaria Symptoms and Quality of Life in Chronic Spontaneous Urticaria Patients. Open access.

A Prospective Case-Control Study
Vitamin D plays an important role in the immune system; decreased serum vitamin D concentrations have been linked to dysregulated immune function. Low vitamin D status is probably associated with chronic spontaneous urticaria (CSU). We evaluated the prevalence of low vitamin D status, and the clinical response and quality of life following vitamin D supplementation, in a prospective case-control study with 60 CSU patients and 40 healthy individuals. Serum 25-hydroxy vitamin D (25(OH)D) concentrations were measured at baseline and after 6 weeks. For patients with 25(OH)D concentrations – 30 ng/ml, treatment included 20,000 IU/day of ergocalciferol (vitamin D2) and non-sedative antihistamine drugs for 6 weeks. Urticaria symptom severity and quality of life
Dermatoendocrinol. 2014; 6: e29727.
Published online Jul 16, 2014. doi:  10.4161/derm.29727
PMCID: PMC4203568


Information and support from dietary consultation for mothers of children with food allergies

Heather MacKenzie, PhD, Jane Grundy, Gillian Glasbey, Taraneh Dean, PhD, Carina Venter, PhD


Professional dietetic input is essential to ensure that children with diagnosed food allergies have an individualized avoidance plan and nutritionally adequate diet. However, it is not clear what dietary information and support parents require.


To explore what information and support parents of children with food allergies require from a dietary consultation.



Mothers of children with food allergies want to understand how to provide a nutritionally adequate, allergen-safe diet while maintaining a normal life. Hence, mothers value a range of support from dietitians, including monitoring their child’s health and providing information, practical advice and support, and emotional support.

Information and support from dietary consultation for mothers of children with food allergies


First Global Allergy-Free Airline Option

allergy holiday airline trave

Great news! This airline is the first one to be certified allergy-free by the European Center for Allergy Research Foundation.

Find out which airline it is here

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